Progesterone Estrogen Steroid Hormone Natural Anabolic Powder Fitness Health
Progesterone, hormone secreted by the female reproductive system that functions mainly to regulate the condition of the inner lining (endometrium) of the uterus. Progesterone is produced by the ovaries, placenta, and adrenal glands.
In the ovaries the site of progesterone production is the corpus luteum. It also inhibits muscular contractions of the uterus that would probably cause the wall to reject the adhering egg. The placenta then produces progesterone during the period of pregnancy.
Progesterone prepares the wall of the uterus so that the lining is able to accept a fertilized egg and so that the egg can be implanted and develop. A fertilized egg that becomes implanted in the uterus will form a placenta. The term progestin is used to describe progesterone and synthetic steroid hormones with progesterone-like properties, such as the progestogen levonorgestrel.
Progesterone, like all other steroid hormones, is synthesized from pregnenolone, a derivative of cholesterol. This conversion takes place in two steps. The 3-hydroxyl group is converted to a keto group and the double bond is moved to C-4, from C-5.
Androstenedione can be converted to testosterone, estrone and estradiol.
Conversion of Pregnenolone to Progesterone
Progesterone is the precursor of the mineralocorticoid aldosterone, and after conversion to 17-hydroxyprogesterone (another natural progestogen) of cortisol and androstenedione.
The Role of Progesterone in Women
One of progesterone's most important functions is to cause the endometrium to secrete special proteins during the second half of the menstrual cycle,
The combination of high estrogen and progesterone levels suppress further ovulation during pregnancy.
If a pregnancy occurs, progesterone is produced in the placenta, and levels remain elevated throughout the pregnancy. Progesterone also encourages the growth of milk-producing glands in the breast during pregnancy.
High progesterone levels are believed to be partly responsible for symptoms of premenstrual syndrome (PMS), such as breast tenderness, feeling bloated and mood swings. When you skip a period, it could be because of failure to ovulate and subsequent low progesterone levels.
preparing it to receive and nourish an implanted fertilized egg. If implantation does not occur, estrogen and progesterone levels drop, the endometrium breaks down and menstruation occurs.
What can I do about low progesterone?
Having low progesterone may not have any symptoms for you, and you may not need to treat it.
For severe symptoms of menopause, hormone therapy usually consists of a combination of estrogen and progesterone. Women who take estrogen without progesterone are at increased risk of developing endometrial cancer.
Menstrual irregularities and abnormal bleeding can also be improved through hormone therapy.
Treatment options include:
vaginal rings, which offer slower releases of hormones than oral medications
oral medications, like Provera
Hormone therapy may help ease symptoms such as hot flashes, night sweats, and vaginal dryness. creams and gels, which can be used topically or, in women, vaginally
suppositories, which are commonly used when treating low progesterone that is causing fertility problemsOral progesterone may provide a calming effect, making it easier to sleep. For some women, it improves mood and state of mind. It may also lower your risk of osteoporosis and diabetes.
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