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|Appearance:||White Power||Molecular Weight:||650.97|
|Chemical Name:||5-Triiodo-L-thyronine||Usage:||Pharmaceutical Intermediates|
|Shelf Life:||2 - 3 Years||Market:||Global|
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L-Triiodothyronine / T3 Na Raw Steroid Powders
CAS No: 6893-02-3
Chemical name: 3, 3', 5-Triiodo-L-thyronine, sodium salt
Molecular formula: C15H12I3NO4
Molecular Weight: 650.97
Content: (%): 99
Appearance: White or light yellow powder
Usage: Pharmaceutical intermediates
Boiling point: 205° C
L-Triiodothyronine / T3 Na Raw Steroid Powders CAS 6893-02-3
Water-solubility: 4 M NH4OH in methanol: 125 g/5mL,
Alias: T3 Na; Triostat; L-Triiodothyronine T3; Liothyronine Sodium Salt; T3 Sodium Salt; Tertroxin; Thyroid hormone; Cynomel; Cytomel sodium; Liothyronine Sodium; L-Triiodothyronine, sodium salt; Sodium L-liothyronine; Sodium L-liothyronine; 3,3',5-Triiodo-L-thyronine, sodium salt
CAS 55-06-1 Description:
Triiodothyronin , e, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.
This pathway is regulated via a closed-loop feedback process: Elevated concentrations of T3, and T4 in the blood plasma inhibit the production of TSH in the pituitary gland. Production of T3 and its prohormone thyroxine (T4) is activated by thyroid- stimulating hormone (TSH), which is released from the pituitary gland. As concentrations of these hormones decrease, the pituitary gland increases production of TSH, and by these processes, a feedback control system is set up to regulate the amount of thyroid hormones that are in the bloodstream.
It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate. The basal metabolic rate is the minimal caloric requirement needed
to sustain life in a resting individual. T3 increases the basal metabolic rate and, thus, increases the body's oxygen and energy consumption.
It increases the production of the Na+/K+ - ATPase and, in general, increases the turnover of different endogenous macromolecules by increasing their synthesis and degradation. T3 acts on the majority of tissues within the body, with a few exceptions including the spleen and testis.
Mechanism of action
The T3 (and T4) bind to nuclear receptors, thyroid receptors. T3 (and T4) are very lipophilic and able to pass through the phospholipid bilayers of target cells. The thyroid receptors bind to response elements in gene promoters, thus enabling them to activate or inhibit transcription.
The lipophilicity of T3 (and T4) requires their binding to the protein carrier thyroid-binding protein (TBG) [thyroxine-binding globulins, thyroxine binding prealbumins, and albumins for transport in the blood.
The sensitivity of a tissue to T3 is modulated through the thyroid receptors.
The transportation of triiodothyronine
There are three main proteins that the two hormones are bound to. Thyronine-binding globulin (TBG) is a glycoprotein that has a higher affinity for T4 than for T3. Transthyretin is also a glycoprotein, but only carries T4, with hardly any affinity at all for T3. Finally, both hormones bind with a low affinity to serum albumin, but, due to the large availability of albumin, it has a high capacity.
T3 and T4 are carried in the blood, bound to plasma proteins. This has the effect of increasing the half-life of the hormone and decreasing the rate at which it is taken up by peripheral tissues.
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