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Yohimbine HCl can lead to increased fat loss, especially in "problem areas," such as the middle section and love handles for men and buttocks and thighs for women. Yohimbine HCl can also support the feeling of well-being and mood and suppress appetite. In its herbal form, yohimbe has been used for centuries as an enhancer and stimulant of performance. More recently, the most powerful, purified and standardized form of yohimbe - Yohimbine HCL - has been used to support fat burning.
Yohimbine HCl is classified as an "alpha-2 adrenoceptor antagonist". Alpha-2 receptors are found mainly in the fat cells of the body. When alpha-2 receptors are activated, the mobilization of free fatty acids is inhibited. By doing so, it acts to block the activation of alpha-2 receptors in fat cells, which helps to release stored fat in the form of fatty acids, and finally burns for energy.
What is it used for?
Yohimbe is being investigated for the treatment of organic impotence, in particular patients with diabetes, and for use as an aphrodisiac. Yohimbe can cause dilation of peripheral blood vessels along with central nervous system stimulation. Therefore, the drug has been investigated for erectile dysfunction. Clinical studies do suggest that yohimbe may be effective in the treatment of male organic impotence.
The bark of the West African yohimbe tree is rich in the alkaloid yohimbine, and both the crude bark and purified compound long have been hailed as aphrodisiacs. The bark has been smoked as a hallucinogen and has been used in traditional medicine to treat angina and hypertension.
How does it work?
Yohimbine blocks pre-and postsynaptic alpha-2 adrenoceptors, this prevents the release of norepinephrine from cells. Norepinepherine stimulates the alpha and beta receptors in a cell. The stimulation of beta-adrenoceptors causes the degradation of fat, while the stimulation of alpha-2 adrenoceptors prevents this degradation of fats. Yohimbine blocks the alpha feedback mechanism, thereby increasing the breakdown of norepinephrine and fat.
In addition, blockade of postsynaptic alpha-2 adrenoceptors leads to relaxation of the smaller cavernous smooth muscle. In fact, most of the adrenoceptors in the corpora cavernosa are alpha-1. These are the properties of Yohimbine and Rauwolscine which means that it is useful in the treatment of erectile dysfunction. This may be useful for those in bodybuilding who are using, or have stopped using AAS recently, since loss of libido and erection problems are a known side effect of these substances.
It should be noted that the abdominal area in men and the glutofemoral area (buttocks) in women contains a higher proportion of alpha-2 receptors, this could make Yohimbine more effective in these areas. In addition, blockade of alpha-2 receptors increases blood flow in fat tissue, which can also prevent fat from being retained or deposited in the area.
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