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|Product Name:||Letrazole||Other Name:||Femara|
Other name: Femara
Appearance: White or light yellow crystal
Usage: Used as API in Treatment of breast disease
Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant treatment of hormonally sensitive breast cancer
Estrogens are produced by the conversion of androgens through the activity of the enzyme aromatase. Letrozole blocks estrogen production in this way through a competitive and reversible binding to the heme of its cytochrome P450 unit. The action is specific and letrozole does not reduce the production of minerals or corticosteroids. On the contrary, the antiestrogenic action of tamoxifen, the main medical therapy prior to the arrival of aromatase inhibitors, is because it interferes with the estrogen receptor, rather than inhibiting estrogen production.
Letrozole Dosage During Anabolic Steroid Use:
Letrozole in particular cannot be categorized into the three tiers of users (beginner, intermediate, and advanced) as normally outlined and listed in common profiles of the different compounds and drugs. This is due to the fact that Letrozole is an ancillary drug not particularly used for the purpose of performance enhancement, but instead is utilized to combat or mitigate various Estrogen-related side effects when aromatizable anabolic steroids are utilized.
For the purpose of Estrogen control during a cycle: Letrozole is the most effective aromatase inhibitor utilized to reduce levels of circulating Estrogen in the body during a cycle involving the use of aromatizable androgens (anabolic steroids that have an affinity to bind to the aromatase enzyme and undergo aromatization into Estrogen). This has been outlined previously in the introduction. Letrozole doses for this purpose cover a very wide range, and how much Letrozole is required (and how often) is also largely dependent on the doses of aromatizable anabolic steroids used, the individual’s sensitivity to aromatase inhibitors, and the rate of aromatization of the anabolic steroids used. With this being said, the general range of Letrozole doses are approximately 1.25mg – 2.5mg daily. There does exist a very large margin for adjustment and user preference when it comes to Letrozole dosages, as each individual should slowly adjust their dose depending on how they feel the body is responding. This is especially so for Letrozole, which is the most powerful and potent AI of the three. Even 1.25mg daily is too much for many anabolic steroid users, and often times the recommended dose is actually 1.25mg every other day, and often can be even less frequent especially considering the half-life of Letrozole is that of 2 – 4 days. These Letrozole doses can easily be adjusted if the user feels it is not working well enough, or if it is reducing Estrogen levels too much.
Letrozole May Interact with Other Medications:
Letrozole can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.
Medical Letrozole Dosage:
Letro is approved by the FDA for the treatment of post-menopausal female breast cancer patients as an adjunctive treatment when first-line treatments (such as Nolvadex) have failed to work. It is also approved for the extended treatment for post-menopausal female breast cancer patients after 5 years of Nolvadex administration. Letrozole is also approved for the treatment of post-menopausal female breast cancer patients that are exhibiting symptoms of Estrogen receptor unknown breast cancer. This is a breast cancer condition in which the diagnosis indicates that it is unknown as to whether or not Estrogen is the culprit, or whether or not the breast cancer is aggravated by Estrogen. Finally, it is also approved for the treatment of post-menopausal female breast cancer patients for whom all other anti-Estrogen compounds have not worked (this includes SERMs and all other AIs). Letrozole is often the last-resort and final treatment attempt for breast cancer patients when all else has failed.
The Letrozole dosage for breast cancer treatment in all cases are that of 2.5mg daily.
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