Aromasin Exemestane CAS 107868-30-4 99.5% Assay for Bodybuilding And Athletics
If you are on the verge of using Aromasin immediately or after your anabolic steroid cycle, it is critical that you have good knowledge of the benefits of the drug, tips while using this drug and also the precautions you need to take while using this drug.
The half-life of Aromasin is only about 9 hours, and clears quickly. However, because of how effective Exemestane is at eliminating Aromatase enzymes (80-90% after administration), estrogen levels will remain low up to 72 hours after a single dose of 25mg. This is why aromasin is very effectively dosed every other day. In one study, users were still 40% below baseline estrogen values 72 hours after their dose. This makes aromasin very versatile for dosing and not require more frequency.
Exemestane (Aromasin) is an oral steroidal aromatase inhibitor, but unlike letrozole and anastrozole it permanently binds to the active site of the aromatase enzymes thus blocking their function of converting androgens into estrogens. This is known as Type I or suicide inhibition because the inhibitor becomes inactive due to the mechanism of its actions.
For bodybuilders this is of significant value because it means that estrogenic rebound is not possible upon the removal of exemestane. Other aromatase inhibitors will disassociate from the enzyme, eventually allowing renewed androgen to estrogen synthesis.
Exemestane is often combined with tamoxifen during PCT. Doing so allows for an enhanced anti-estrogenic effect when both the enzyme (exemestane) and receptor (tamoxifen) sites are blocked. The added advantage of using exemestane over other aromatase inhibitors is that the aromatase enzyme stays deactivated long after the PCT protocol finishes. This prevents estrogenic activity from resuming immediately and thus causing estrogenic side-effects again. Instead the aromatase enzymes will slowly return to normal function. The addition of tamoxifen also has a positive effect on cholesterol.
Aromasin dosed at 25mg per day increased total testosterone by 60% in only 10 days. Even better than that, is the fact that free (useable) testosterone increased over 100% in the same time frame! In addition, Aromasin also increases IGF-1 levels. There is no estrogen rebound from Aromasin, and it is also a very powerful and effective treatment for gynecomastia. All of this makes Aromasin a no-brainer for post cycle therapy as well as on cycle estrogen control.
Exemestane's half life in the male body is actually very short (~9 hours) and it is quickly eliminated, however, since as soon as it enters your bloodstream it quickly destroys 80-90% of the aromatase enzymes present in your body, it is effective in maintaining significant reductions in estrogen for up to 72 hours after a single 25mg dose. Estrogen levels only begin to rise again after your body has begun to make new aromatase enzymes to replace the ones destroyed by exemestane.
There is a great study on the pharmacokinetics of exemestane in men which found the following:
-24 hours after one 25mg dose estrogen levels are reduced by 70-80%
-72 hours later estrogen levels are still 40% below baseline even though the drug itself is almost completely eliminated
-120 hours after initial dose estrogen levels return to baseline (without rebounding)
This means that you can find the timing and dosage that works for you, I've seen some guys recommend between 25mg ed and 12.5mg e4d, and you can see why both are effective while providing different levels of estrogen suppression, and it is this flexibility that makes exemestane such a versatile anti-estrogen.
||Tamoxifen Citrate (Nolvadex)
||Clomiphene Citrate (Clomid)
||Toremifene Citrate (Fareston)