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|Product Name:||L-triiodothyronine||Other Name:||T 3|
|Appearance:||White Powder||Function:||Muscle Growth|
|Policy:||Reship Policy||Factory Price:||YES|
Triiodothyronine, also known as T3, is a thyroid hormone. This affects almost all physiological processes in the body including growth and development, metabolism, body temperature and heart rate.
The production of T3 and its prohormone thyroxine (T4) are activated by the thyroid stimulating hormone (TSH), which is released from the anterior pituitary gland. This pathway is part of a closed loop feedback process: high T3 and T4 concentrations in blood plasma inhibit TSH production in the anterior pituitary gland. As concentrations of these hormones decrease, the anterior pituitary gland increases TSH production, and by these processes a feedback control system stabilizes the amount of thyroid hormones that are in the bloodstream.
T3 is the true hormone. Its effects on target tissues are approximately four times more potent than those of T4. Of the thyroid hormone that is produced, only about 20% is T3, while 80% is produced as T4. About 85% of circulating T3 is subsequently formed in the liver and anterior pituitary by removal of the iodine atom from the carbon atom number five of the outer ring of T4. In any case, the concentration of T3 in human blood plasma is about one-fortieth that of T4. The half-life of T3 is about 2.5 days.
T3 increases the basal metabolic rate and, thus, increases the body's oxygen and energy consumption.
T3 stimulates the production of RNA Polymerase I and II and, therefore, increases the rate of protein synthesis. It also increases the rate of protein degradation, and, in excess, the rate of protein degradation exceeds the rate of protein synthesis.
T3 potentiates the effects of the β-adrenergic receptors on the metabolism of glucose. Therefore, it increases the rate of glycogen breakdown and glucose synthesis in gluconeogenesis.
T3 stimulates the breakdown of cholesterol and increases the number of LDL receptors, thereby increasing the rate of lipolysis.
T3 increases the heart rate and force of contraction, thus increasing cardiac output, by increasing β-adrenergic receptor levels in myocardium. This results in increased systolic blood pressure and decreased diastolic blood pressure. The latter two effects act to produce the typical bounding pulse seen in hyperthyroidism. It also upregulates the thick filament protein myosin, which helps to increase contractility. A helpful clinical measure to assess contractility is the time between the QRS complex and the second heart sound. This is often decreased in hyperthyroidism.
T3 has profound effect upon the developing embryo and infants. It affects the lungs and influences the postnatal growth of the central nervous system. It stimulates the production of myelin, the production of neurotransmitters, and the growth of axons. It is also important in the linear growth of bones.
T3 may increase serotonin in the brain, in particular in the cerebral cortex, and down-regulate 5HT-2 receptors, based on studies in which T3 reversed learned helplessness in rats and physiological studies of the rat brain.
Thyroid hormones act to increase protein turnover. This might serve an adaptive function in regard to long-term calorie restriction with adequate protein. When calories are in short supply, reduction in protein turnover may ameliorate the effects of the shortage.
|Appearance||An odorless, almost white or buff colored powder||pass|
|Solubility||1,Very slightly soluble in water||pass|
|2,slightly soluble in alcohol||pass|
|3,practically insoluble in most other organic solvents||pass|
|4,disolves in diluted aqueous sodium hydroxide solutions||Pass|
|Identification||a) Heat about 50 mg with a few drops of sulfuric acid in a porcelain crucible: violet vapors of iodine are evolved.||pass|
|b)The retention time of the major peak is confirm to the RS||pass|
|Loss on Drying||Not more than 4.0%||0.46%|
C=1 in 1M HCl/EtOH 1:4
|+18 ~ +22o||+20.9o|
|Assay(HPLC)||Not less than 95.0%||99.18%|
|Levothyroxine sodium||Not more than 5.0%||0.68%|
|Conclusion:||Up to the Standard for Export|
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