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|Traits:||White Freeze Dried Powder||Chemical Name:||Erythropoietin|
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What is Erythropoietin
Erythropoietin (EPO) is a peptide hormone that runs on its natural course inside every human body.Erythropoietin receptor (EPOR) includes receptor for growth hormone, granulocyte-colony stimulating factor, thrombopoietin and others. It controls the production of red blood cells in the bone marrow, responsible for transporting additional oxygen to cells that produce energy during a physical activity.
Erythropoietin (EPO) is a hormone that regulates red blood cell production. Recombinant human EPO (rHuEPO) and NESP (novel erythropoiesis stimulating protein) have been produced for therapeutic purposes and also to improve sports performance.
The primary sequences of rHuEPO and NESP differ by just five amino acids. The sera obtained were tested by ELISA on synthetic peptide–OVA conjugates and purified by immunoaffinity chromatography against the corresponding synthetic peptide. The specific purified antibodies were characterized by ELISA, SDS-PAGE, and isoelectric focusing, followed by western blot. Antisera raised against EPO (81–95) recognized rHuEPO but not NESP.An efficient strategy for generating specific antibodies against EPO and NESP can be achieved by selecting suitable synthetic peptides.
The aim of the present work was to design synthetic peptides corresponding to the sequence that differs between EPO and NESP (87–90aa), that can then be used as immunogens to develop specific rabbit polyclonal antibodies for selectively detecting EPO and NESP. In contrast, anti-NESP (84–106) sera gave a specific anti-NESP response only after immunoaffinity purification on a NESP (86–91) column.
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Due to the high homology, no antibodies that are able to discriminate between both molecules have been obtained until now.Three peptides were synthesized: EPO (81–95), NESP (81–95), and NESP (86–104), and these were coupled to KLH and OVA for immunization and screening purposes, respectively. The antibodies obtained are able to differentiate between rHuEPO and NESP, and may be particularly useful for screening purposes in both therapeutic and antidoping contexts.
Results and benefits
EPO is commonly used for the treatment of severe anemia caused by acute and chronic diseases. In this sense, EPO treats problems like chronic kidney disease, anemia induced by cancer, inflammatory bowel disease and myelodysplasia derived from the treatment of cancer. EPO can function as a complementary hormonal treatment of any potential drug treatment.
People with this kind of disease may have chronic fatigue; that decreases their life quality, their relationships and their daily activities. This condition can be controlled by providing them this peptide.
EPO has been used like a “Performance-Enhancing Drug” (PED) to improve the performance of physical activity in humans.
EPO stimulates the angiogenesis, resulting in the forming of new vessels from pre-existing vessels. Angiogenesis is the responsible for the growth and development of vessels, as well as wound healing and the formation of granulation tissue, which is formed at the site of an injury to begin a healing process.
Athletes often use these substances to get an advantage over their competitors. EPO is a blood booster, and it is good for long-distance running, cycling and skiing.