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|Product Name:||Anastrozole||Feature:||White Powder|
|Usage:||Muscle Growth||Standard:||Enterprise Standard|
Other name: Arimidex
Appearance: off-white color crystalline powder
Usage: It can be used to the treatment of Breast cancer
Arimidex belongs to a category and class of drugs known as aromatase inhibitors (AIs). Aromatase inhibitors belong to an even broader class of drugs known as anti-estrogens. The other subcategory of drug under the anti-estrogens category is known as selective estrogen receptor modulators (SERMs), such as Nolvadex and Clomid. AIs and SERMs make up anti-estrogens. Aromatase inhibitors differ greatly from SERMs in their action and how they deal with the issues of estrogen control. The misunderstanding that SERMs, such as Nolvadex and Clomid, serve to lower estrogen levels must first be addressed. This is a persistent rumor among the anabolic steroid using community that has begun to erode as of late, but the rumor still persists. SERMs serve to block the action of Estrogen at the receptor sites in breast tissue by occupying the receptor sites in place of Estrogen so that Estrogen itself cannot exert its effects there through receptor site binding. Conversely, SERMs will also act as Estrogens at receptor sites at other cells in other areas of the body (the liver, for example in Nolvadex’s case). SERMs do not lower circulating levels of Estrogen in blood plasma. Aromatase inhibitors serve to do this by eliminating the production of Estrogen through binding to and disabling the aromatase enzyme, which is the enzyme responsible for the conversion (or aromatization) of androgens into Estrogen.
Arimidex and Letrozole are both classified as non-steroidal and non-suicidal aromatase inhibitors that compete with the substrate for binding to the enzyme active site. This is very different from Aromasin (Exemestane), which is a steroidal and suicidal aromatase inhibitor that acts as a mechanism-based steroidal inhibitor that mimics the substrate, is converted by the enzyme to a reactive intermediate, and results in the inactivation of the aromatase enzyme . For ease of understanding, what this means to the layman is that Aromasin’s chemical structure resembles the traditional ‘targets’ that aromatase binds to (Testosterone, for example) and that it essentially ‘fools’ the aromatase enzyme into binding with it, only to become inhibited/deactivated. Because the binding strength is so great, this inhibition becomes permanent for the aromatase enzyme that Aromasin has become bound to. Arimidex and Letrozole, being non-suicidal aromatase inhibitors, both compete with the enzyme’s traditional ‘targets’ rather than being assured a permanent spot (which is the advantage that Aromasin has over the other two).
Dosing and Administration of Arimidex:
Medically, Arimidex (Anastrozole) is utilized as a medication in the treatment of post-menopausal female breast cancer where Estrogen has been determined to be the prime cause. The prescription dosing and administration of Arimidex in these cases call for 1mg taken once per day, until the progression of the cancer has stopped.
Arimidex Dosages During Anabolic Steroid Use:
Arimidex in particular cannot be categorized into the three tiers of users (beginner, intermediate, and advanced) as normally outlined and listed in common profiles of the different compounds and drugs. This is due to the fact that Arimidex is an ancillary drug not particularly used for the purpose of performance enhancement, but instead is utilized to combat or mitigate various Estrogen-related side effects when aromatizable anabolic steroids are utilized. In some instances, Arimidex doses might possibly also be utilized to increase the endogenous Testosterone secretion in men, which allows this compound to be utilized as an ancillary medication during PCT (Post Cycle Therapy) phases following the end of an anabolic steroid cycle, but its use on its own for this purpose is not very common and is unlikely to produce noticeable performance enhancing effects.
For the purpose of Estrogen control during a cycle: Arimidex can be effectively utilized to reduce levels of circulating Estrogen in the body during a cycle involving the use of aromatizable androgens (anabolic steroids that have an affinity to bind to the aromatase enzyme and undergo aromatization into Estrogen). Arimidex dosages for this purpose cover a very wide range, and how much Arimidex is required how often is also largely dependent on the doses of aromatizable anabolic steroids used, the individual’s sensitivity to aromatase inhibitors, and the rate of aromatization of the anabolic steroids used. With this being said, the general range of Arimidex doses are 0.5 – 1mg daily. There is much leeway when it comes to this, as each individual should slowly adjust their dose depending on how they feel the body is responding. Even 0.5mg daily is too much for many anabolic steroid users, and often times the recommended dose is actually 0.5mg every other day of Arimidex. These Arimidex doses can easily be adjusted if the user feels it is not working well enough, or if it is reducing Estrogen levels too much.
Always remember that the idea with the use of aromatase inhibitors is to control Estrogen levels and bring them back to normal physiological levels as opposed to the complete reduction and/or elimination of them, which will cause problems in the body.
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