CAS 171599-83-0 Sildenafil Citrate Pills Vigra Oral Tablets USP / BP Certification
Generic Viagra refers to a product that contains the active ingredient in Viagra (silendafil) in the same strength ( 25 mg, 50 mg, 100 mg) as the branded version. Generic Viagra is usually labeled as silendafil.
It does not pretend to be Viagra brand silendafil although most of the time so-called generic Viagra will be colored blue and may have the characteristic diamond shape associated with the real thing.
Do not take sildenafil
If you are taking medicines called nitrates, as the combination may lead to a dangerous fall in your blood pressure. Tell your doctor if you are taking any of these medicines which are often given for relief of angina pectoris (or “chest pain”). If you are not certain, ask your doctor or pharmacist.
If you are allergic to sildenafil or any of the other ingredients of this medicine .
If you have certain rare inherited eye diseases (such as retinitis pigmentosa).
If you have a severe heart or liver problem.
If you are using any of the medicines known as nitric oxide donors such as amyl nitrite (“poppers”) as the combination may also lead to a dangerous fall in your blood pressure.
If you have recently had a stroke or a heart attack, or if you have low blood pressure.
If you have ever had loss of vision due to non-arteritic anterior ischaemic optic neuropathy.
Mechanism of action
NO binds to the receptors of the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation (vasodilation) in the corpus cavernosum, resulting in increased inflow of blood and an erection.
Part of the physiological process of erection involves the parasympathetic nervous system causing the release of nitric oxide (NO) in the corpus cavernosum of the penis.
The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections.
Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection. Other drugs that operate by the same mechanism include tadalafil (Cialis®) and vardenafil (Levitra®).
What is the difference between Viagra and Sildenafil?
Sildenafil is the active ingredient in Viagra and is available in a generic, unbranded tablet. Sildenafil and Viagra are medically equivalent but Sildenafil is available at a much lower cost. Generic medicines contain the same active ingredient and are equally effective and medically equivalent as the branded products but are available at a lower price.
Generic manufacturers have to demonstrate that they are medically identical to the branded product - i.e. they offer the same quality, strength, stability and effectiveness.
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