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Nutrobal (Mk-677)
 
Nutrobal (Mk-677) is an orally administrated growth hormone secretagogue originally developed by Reverse Pharmacology. This GHS (Growth Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete growth hormone. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety. In other words, Nutrobal could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn’t require any injections nor does it have any side effects like GHRP-6.
 
 
MK-677 for Dieting
 
In order for a diet – any diet – to work, an organism's expended energy must be greater than its caloric intake.
The more lost nitrogen one experiences during dieting, the more protein, and consequently, muscle, is forfeit. Beginning with the second week, when half of the subjects received MK-677, those subjects improved their nitrogen balance for the remaining the seven days of treatment – in contrast, the group that received the placebo continued to lose muscle.
 
 
However, MK-677, an oral compound that has been proven to increase the body's production of Growth Hormone (GH), can not only help the body hold onto muscle during periods of calorie restriction, but can actually reverse muscle loss (catabolism) under those conditions.
 
 
Put simply, you need to eat fewer calories than you're burning. However, being in a hypocaloric state has unwanted consequences, which typically include the loss of hard-earned muscle mass.
 
 
Over the first week of caloric restriction, the scientists observed and measured the nitrogen (protein) losses in the subjects.
 
 
The bottom line is that 20mgs per day of MK-677 is especially useful for anyone not eating enough calories, as it will certainly prevent muscle loss, perhaps aid in building more muscle, but will also accelerate fat loss as well.
 
 
The group receiving MK-677 showed higher GH levels than the placebo group, as well as higher levels of Insulin-like Growth Factor-1. Because both GH and IGF-1 are well known to reduce body fat and build muscle, the long term effects of this type of treatment would be unlikely to end with simply allowing dieters (or anyone in a hypocaloric state) to retain muscle, but would most likely allow them to build more muscle and lose more fat.
 
 
How it Works
 
Growth hormone pulse intensity can be increased through 4 possible mechanisms:
Increasing GHRH (growth hormone releasing hormone) release
Inhibiting of somatostatin receptor signaling
Reducing somatostatin release (somatostatin turns off GH release)
Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland
 
 
After ingestion, Growth Hormone (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day. Nutrobal (Mk-677) was found to work through all four of these mechanisms.
 
 
 
Stacking info
 
MK677 is a very powerful drug which can be used for both cutting and bulking to great effect.
However, the drug has very few, if any, interactions so can be run alongside other compounds including HCG, SARMs and anabolic steroids. A solo MK677 cycle is sufficient to deliver impressive fat loss combined with a significant increase in lean muscle tissue. Therefore if you want to create a MK677 super stack, you can expect some of the best results possible.
 
 
 
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