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What Is Orlistat?
Orlistat 120mg is used in the treatment of obesity. By reducing the amount of fat that is absorbed, Orlistat can help you to lose weight more easily. Orlistat prevents your body from absorbing the fat from the food you eat.
When should you use Orlistat?
If you have previously tried losing weight through diet and exercise and have not had the desired results you may wish to consider trying to use Orlistat.
Orlistat is only suitable for people with a BMI over 30 or for people with a BMI over 28 who have conditions related to weight such as diabetes or high blood pressure.
Orlistat is clinically proven to help you lose 50% more weight than through dieting alone.
Use our online BMI calculator to calculate your BMI.
How does Orlistat Work ?
Enzymes in your digestive system, called lipases, help digest (or break down) fat. When taken with meals, Orlistat attaches to the lipases and blocks them from breaking down some of the fat you have eaten.
Orlistat works in a unique way. The active ingredient, Orlistat, attaches itself to some of the body’s natural enzymes that break down fat, so you don’t absorb it. This prevents some of the fat you eat from being absorbed.
Orlistat works in your digestive system to block about one-third of the fat in the food you eat from being digested.
If you eat an excessive amount of fat or calories, the excess is stored as fat by the body, resulting in weight gain. When you eat fat, your body breaks it down into its simplest components so that it can be digested.
The undigested fat cannot be absorbed and is eliminated in your bowel movements. By working this way, Orlistat helps block about one-third of the fat in the foods you eat from being absorbed by your body.
Orlistat isn’t a stimulant or an appetite suppressant. The safety and efficacy of Orlistat, has been established in more than 100 clinical studies with data from over 30,000 people. It's formulated to work only in your digestive system and should not affect your heart rate, your brain or cause sleeplessness.
Only trace amounts of orlistat are absorbed systemically; the primary effect is local lipase inhibition within the GI tract after an oral dose.
Orlistat works by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine.
The primary route of elimination is through the feces. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested.
At the standard prescription dose of 120 mg three times daily before meals, orlistat prevents approximately 30% of dietary fat from being absorbed,and about 25% at the standard over-the-counter dose of 60 mg. Higher doses do not produce more potent effects.
The amount of weight loss achieved with orlistat varies. Between 16.4% and 24.8% achieved at least a 10% decrease in body mass. After orlistat was stopped, a significant number of subjects regained weight—up to 35% of the weight they had lost.
In one-year clinical trials, between 35.5% and 54.8% of subjects achieved a 5% or greater decrease in body mass, although not all of this mass was necessarily fat.Despite this relatively small body mass effect, there was a 37% reduction in the incidence of type 2 diabetes, a significant difference.
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