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muscle building steroids
Aromasin/Exemestane CAS 107868-30-4
Exemestane, sold under the name Aromasin? by Pfizer, is an orally available suicidal aromatase inhibitor. This sentence describes exactly why exemestane is the king of Anti-E's for bodybuilding purposes. Estrogen levels only begin to rise again after your body has begun to make new aromatase enzymes to replace the ones destro by exemestane.
There is a great study on the pharmacokinetics of exemestane in men which found the following:
-24 hours after one 25mg dose estrogen levels are reduced by 70-80%
-72 hours later estrogen levels are still 40% below baseline even though the drug itself is almost completely eliminated
-120 hours after initial dose estrogen levels return to baseline (without rebounding)
Steroidal anti-estrogens have the benefit of being lipid-friendly and they all lower SHBG which increases the ratio of free to bound testosterone, which as many experienced BB'ers know can have a relatively profound positive impact on gains.
this means that you can find the timing and dosage that works for you, I've seen some guys recommend between 25mg ED and 12.5mg e4d, and you can see why both are effective while providing different levels of estrogen suppression, and it is this flexibility that makes exemestane such a versatile Anti-E.
Exemestane's half life in the male body is actually very short (~9 hours) and it is quickly eliminated, however, since as soon as it enters your bloodstream it quickly destroys 80-90% of the aromatase enzymes present in your body, it is effective in maintaining significant reductions in estrogen for up to 72 hours after a single 25mg dose.
Because exemestane is steroidal this gives it a favorable estrogen suppression profile and confers a few really awesome benefits over other anti-estrogens both on paper and in real experience.
Aromasin is used to fight breast cancer and raise testosterone in the body.
Exemestane blocks the process of aromatisation. In advanced breast cancer the cancer cells may grow more slowly or stop growing completely. So it lowers the amount of oestrogen in the body. In early breast cancer, taking exemestane can help to stop breast cancer coming back.
Exemestane is an aromatase inhibitor. In the absence of estrogen, tumors dependent on this hormone for growth will shrink. This means it blocks the enzyme aromatase (found in the body's muscle, skin, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogen.
The good Aspects :
- powerful aromatase inhibitor capable of stopping gynecomastia completely on its own (for aromatizing compounds)
- NO adverse changes in lipid profiles for men (granted if you are using it on cycle this may be different)
- has powerful bloat-reduction effects
- is NOT liver toxic
- can actually boost Libido on and off cycle
- increases IGF-1
- no estrogen rebound
- lowers SHBG, increasing free test & makes all other anabolic steroids more bio-available (read: more gains)
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